Akinetic‐rigid and tremor‐dominant Parkinson's disease patients show different patterns of FP‐CIT Single photon emission computed tomography
Identifieur interne : 001816 ( Main/Exploration ); précédent : 001815; suivant : 001817Akinetic‐rigid and tremor‐dominant Parkinson's disease patients show different patterns of FP‐CIT Single photon emission computed tomography
Auteurs : Carsten Eggers [Allemagne] ; Deniz Kahraman [Allemagne] ; Gereon R. Fink [Allemagne] ; Matthias Schmidt [Allemagne] ; Lars Timmermann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-02-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Aged, Brain Mapping, Corpus Striatum (pathology), Corpus Striatum (radionuclide imaging), Female, Fluorine Radioisotopes (diagnostic use), Human, Humans, Iodine, Iodine‐123 fluoropropyl–carbomethoxy‐3 β‐single photon emission computed tomography, Male, Middle Aged, Muscle Rigidity (etiology), Muscle Rigidity (radionuclide imaging), Nervous system diseases, Parkinson Disease (complications), Parkinson disease, Parkinson subtype, Parkinson's disease, Severity of Illness Index, Single photon emission tomography, Subtype, Tomography, Emission-Computed, Single-Photon (methods), Tremor, Tremor (etiology), Tremor (radionuclide imaging), Tropanes (diagnostic use), visual analysis.
- MESH :
- chemical , diagnostic use : Fluorine Radioisotopes, Tropanes.
- complications : Parkinson Disease.
- etiology : Muscle Rigidity, Tremor.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Corpus Striatum.
- radionuclide imaging : Corpus Striatum, Muscle Rigidity, Tremor.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Objective:: To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine‐123 fluoropropyl–;carbomethoxy‐3 β‐(FP‐CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings. Methods:: We analyzed a database of consecutive patients with FP‐CIT scan (n = 190) over a 3‐year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP‐CIT scan results were analyzed and compared for the subgroups tremor‐dominant versus akinetic‐rigid and equivalent type of Parkinson's disease. Results:: The analysis of all Parkinson's disease patients showed a significant difference between the FP‐CIT uptake in the subgroups tremor‐dominant and akinetic‐rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa‐equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference (P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP‐CIT SPECT and clinical Parkinson's disease subtype. Conclusion:: These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic‐rigid patients as well as the lateral putamen and caudate nucleus in tremor‐dominant patients in vivo. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23468
Affiliations:
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Le document en format XML
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<term>Fluorine Radioisotopes (diagnostic use)</term>
<term>Human</term>
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<term>Iodine</term>
<term>Iodine‐123 fluoropropyl–carbomethoxy‐3 β‐single photon emission computed tomography</term>
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<term>Muscle Rigidity (etiology)</term>
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<front><div type="abstract" xml:lang="en">Objective:: To elucidate whether Parkinson's disease subtypes show a different pattern of Iodine‐123 fluoropropyl–;carbomethoxy‐3 β‐(FP‐CIT) single photon emission computed tomography (SPECT) binding in accordance with neuropathological findings. Methods:: We analyzed a database of consecutive patients with FP‐CIT scan (n = 190) over a 3‐year period and identified 122 patients (50 women, 72 men, mean age 62 ± 11.1 years) with a diagnosis of idiopathic Parkinson's disease. Patient's characteristics and FP‐CIT scan results were analyzed and compared for the subgroups tremor‐dominant versus akinetic‐rigid and equivalent type of Parkinson's disease. Results:: The analysis of all Parkinson's disease patients showed a significant difference between the FP‐CIT uptake in the subgroups tremor‐dominant and akinetic‐rigid. After matching these samples for age, disease duration, disease severity (Hoehn & Yahr grade, Unified Parkinson's Disease Rating Scale score), and levodopa‐equivalent dose, these findings were balanced between both groups (n = 23/23) without a significant difference (P > 0.05). However, there was a clear, significant association of visually analyzed shapes of the striatum in FP‐CIT SPECT and clinical Parkinson's disease subtype. Conclusion:: These results confirm neuropathological models for a reduced dopaminergic projection to the dorsal putamen in akinetic‐rigid patients as well as the lateral putamen and caudate nucleus in tremor‐dominant patients in vivo. © 2011 Movement Disorder Society</div>
</front>
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<name sortKey="Fink, Gereon R" sort="Fink, Gereon R" uniqKey="Fink G" first="Gereon R." last="Fink">Gereon R. Fink</name>
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<name sortKey="Kahraman, Deniz" sort="Kahraman, Deniz" uniqKey="Kahraman D" first="Deniz" last="Kahraman">Deniz Kahraman</name>
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<name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
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